The emergence of so-called Next Generation Sequencers (NGS) is enabling the analysis of DNA/RNA sequence with much less cost and effort than ever. Among others, Illumina Genome Analyzer is one of the most popular choices, because of its excellent cost-performance ratio. Research associate professor Kensuke Nakamura together with professor Shigehiko Kanaya identified that some of the sequencing errors by Illumina GA are associated with specific sequence patterns. Based on this knowledge, it would be possible to further enhance the high potential of Illumina sequencers. For instance, the identification of SNPs and assemble of unknown genome would become more feasible and reliable.